A $2-billion effort was required to obtain sufficient amounts of the two necessary isotopes, uranium-235 and plutonium-239. At Oak Ridge, Tenn., the desired uranium-235 was separated from the much more abundant uranium-238 by a laborious process called gaseous diffusion. At the Hanford installation (Wash.), huge nuclear reactors were built to transmute nonfissionable uranium-238 into plutonium-239. This method was based on the principle of the self-sustaining nuclear reaction (nuclear pile) that had first been achieved under the leadership of Enrico Fermi at the metallurgical laboratory of the Univ. of Chicago. At the radiation laboratory of the Univ. of California at Berkeley costly efforts were made to separate the two uranium isotopes using cyclotrons, but only about a gram of pure uranium-235 was obtained. The actual design and building of the plutonium and uranium bombs took place at Los Alamos, N.Mex., under the leadership of J. Robert Oppenheimer. Gathered at this desert laboratory was an extraordinary group of American and European-refugee scientists.

The only nuclear test explosion, code-named Trinity, was of a plutonium device; it took place on July 16, 1945, near Alamogordo, N.Mex. The first uranium bomb ( "Little Boy" ) was delivered untested to the army and was dropped on Hiroshima on Aug. 6, 1945, killing at least 70,000 inhabitants. On Aug. 9, 1945, a plutonium bomb virtually identical to the Trinity device was dropped on Nagasaki, killing at least 35,000 inhabitants.

See L. R. Groves, Now It Can Be Told (1962); L. Lamont, Day of Trinity (1965); H. Feis, The Atomic Bomb and the End of World War II (rev. ed. 1966); R. Rhodes, The Making of the Atomic Bomb (1987); R. S. Norris, Racing for the Bomb (2002).